Phamaceutical Compuond
CREATE
Compound Facility
2900 Argentia Rd, Mississauga, ON
Jan 2022
S.O.W:Â
- Installation of new commercial HVAC system including brand new make up air unit
- Installation of new HVAC system with rooftop unitÂ
- Installation of gas lines throughout building
- Installation of refrigeration for heat pump unitsÂ
- Installation of HEPA filters for fancoil units
- Installation of pressure censoring monitors throughout compound rooms
Key Installations:
- New Commercial HVAC System with Make-Up Air Unit
- Rooftop HVAC Unit Installation
- Comprehensive Gas Line Infrastructure
- Refrigeration System for Heat Pump Units
- HEPA Filters for Fan Coil Units
- Advanced Pressure Sensing Monitoring System for Compound Rooms
The project aimed to enhance the facility’s ability to maintain precise environmental conditions required for pharmaceutical research, ensuring compliance with regulatory standards while optimizing system performance.
Project Overview
Challenges
- Complex Environmental Control
The pharmaceutical facility required precise control over temperature, humidity, and air quality for research purposes. Maintaining consistent environmental conditions was critical to the success of the facility’s operations.
- Technical Integration of Multiple Complex Systems
Coordinating the installation of multiple complex systems, including HVAC, gas lines, refrigeration, and air filtration, posed logistical challenges and required careful planning to ensure seamless system integration.
- Regulatory Compliance
As a pharmaceutical facility, CREATE had to meet stringent industry regulations for environmental control, safety, and air quality to maintain its certifications and continue its critical work.
Solutions
- Complex Environmental Control
To meet these demands, an advanced HVAC system, including a make-up air unit and rooftop unit, was installed to maintain optimal temperature and air quality. Additionally, an advanced pressure-sensing monitoring system was implemented for the compound rooms to ensure controlled environments. HEPA filters were added to fan coil units to ensure the air quality met strict pharmaceutical standards
- Technical Integration of Multiple Complex Systems
A phased installation approach was employed to ensure smooth coordination between all systems. Each system was installed sequentially, with technical teams working in parallel to ensure that the systems were synchronized for optimal performance. This approach minimized disruption to facility operations while ensuring all systems were properly integrated.
- Regulatory Compliance
To ensure compliance, high-grade HEPA filters were installed in the fan coil units to guarantee the highest level of air filtration and meet cleanliness standards. The pressure-sensing monitoring system was also implemented to maintain the correct pressure differential in the compound rooms, which is essential for preventing contamination. These upgrades exceeded local pharmaceutical facility standards and ensured the facility remained compliant with all necessary regulations.
Implementation Process
- Pre-Installation Planning:
A thorough assessment of the facility’s existing infrastructure was conducted to identify areas of improvement. A detailed project plan was developed, outlining each system’s scope, installation sequence, and timeline to minimize disruption. - Phased Installation:
The installation was carried out in phases, starting with the HVAC system and followed by gas lines, refrigeration, and filtration. This allowed for a smooth transition and ensured each system was properly calibrated before moving to the next phase. - Collaboration with Facility Management:
Close coordination with CREATE’s management was crucial for minimizing disruptions. Work was scheduled during off-hours to avoid interference with ongoing operations, and temporary solutions were provided to maintain functionality during installation. - Testing and Calibration:
After installation, each system underwent extensive testing to ensure it met performance and regulatory standards. The systems were calibrated to ensure optimal functionality and compliance with environmental control requirements.
Results and Impact
- Enhanced Environmental Control:
The new HVAC system, pressure monitoring system, and HEPA filtration ensured that CREATE maintained the precise environmental conditions required for pharmaceutical research, enhancing both safety and research quality. - Increased Operational Efficiency:
The upgrade to more efficient HVAC and refrigeration systems improved the facility’s energy efficiency, reducing operational costs and improving the facility’s long-term sustainability. - Regulatory Compliance:
The facility now meets or exceeds all local pharmaceutical regulations, ensuring ongoing compliance with health and safety standards. The installation of HEPA filters and the pressure-sensing monitoring system contributed to maintaining the required air quality and pressure differentials. - Minimal Disruption:
The phased installation approach allowed CREATE to continue its operations with minimal interruptions. Temporary solutions and careful scheduling ensured that business continuity was maintained during the project.
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Conclusion
The HVAC and infrastructure upgrade at CREATE pharmaceutical facility has successfully enhanced the facility’s environmental control and operational efficiency. By overcoming challenges related to system integration, compliance, and environmental control, the project delivered a modernized and compliant facility that supports ongoing pharmaceutical research. This case study demonstrates the importance of careful planning, technical expertise, and regulatory compliance in successfully executing complex infrastructure upgrades in specialized environments.